CYTOCHALASIN-B INDUCES ABNORMAL CHROMOSOME SEGREGATION IN FRIEND-ERYTHROLEUKEMIA CELLS

  • 1 January 1981
    • journal article
    • research article
    • Vol. 25  (1) , 215-217
Abstract
Friend erythroleukemia cells were made binucleate by brief exposure to cytochalasin B (CB). The binucleate cells were then allowed to grow in the absence of CB. They produced pseudotetraploid derivatives which subsequently showed considerable variation in chromosome number. Cells with abnormal chromosome numbers failed to form clones and dispppeared from the culture. This is in marked contrast to previously reported stable pseudotetraploid cells arising in baby hamster kidney (BHK) cells after CB treatment.

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