Models for Deposition, Retention and Clearance of Particles after Dust Overloading of Lungs in Rats
- 1 January 1994
- journal article
- Published by Oxford University Press (OUP) in Annals of Work Exposures and Health
- Vol. 38, 303-311
- https://doi.org/10.1093/annhyg/38.inhaled_particles_vii.303
Abstract
The toxicokinetic aspects of lung overloading were investigated in subchronic and chronic inhalation studies with particles of low solubility. Test materials were toner for copy machines, TiO2, PVC and diesel soot particles. Three different kinetic models to describe the time course of lung retention were applied and compared. A semi-empirical one-compartment model using clearance rate depending on normalized lung burden and a deposition rate increasing with minute volume was useful for calculation of lung burdens of different particles during chronic inhalation studies. For subchronic inhalation studies with a recovery period a more complex two-compartment model was more suitable for describing lung retention.Keywords
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