Growth factor second messenger systems: Oncogenes and the heterotrimeric GTP‐;binding protein connection
- 1 January 1993
- journal article
- review article
- Published by Wiley in Medicinal Research Reviews
- Vol. 13 (1) , 105-123
- https://doi.org/10.1002/med.2610130105
Abstract
We feel that there is now compelling evidence that the GTP-binding proteins play more than just a coordinating role in the actions of both tyrosine kinase and nontyrosine kinase receptor signal transduction. These similarities appear to represent just a small component of the convergence in the signaling pathways for structurally dissimilar receptor subsets. Future years will see further understanding of the intricacies of these G-protein-proto-oncogene interactions, and the extension into the potential role in growth factor action played by the expanding number of known members of this G-protein family.Keywords
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