Delayed Hemolysis Resulting from Anti-A1 after Liver Transplantation
Open Access
- 1 February 1989
- journal article
- case report
- Published by Oxford University Press (OUP) in American Journal of Clinical Pathology
- Vol. 91 (2) , 232-235
- https://doi.org/10.1093/ajcp/91.2.232
Abstract
The authors report a case of a delayed hemolytic transfusion reaction in a type A2 recipient of a type O liver allograft. An anti-A1 antibody reactive at 37 °C in the indirect antiglobulin test was identified both in the patient’s serum and in an eluate. Hemolysis secondary to the production of anti-A1 has been reported to be extremely rare. The English-language literature has six cases before 1979. During the 1980s, an additional seven cases were reported; six involved transplantation of a solid organ, and in each such case the donor was type O and the recipient was type A1 or A2. Recommendations regarding transfusion practice in such cases are made. An association among the transplantation of a type O organ to a type A recipient, the use of cyclosporine, and an apparent increase in the occurrence of clinically significant anti-A1 is suggested.Keywords
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