Analysis of Polar Organic Compounds Using Charge Exchange Ionization and Membrane Introduction Mass Spectrometry
- 1 July 1996
- journal article
- Published by American Chemical Society (ACS) in Analytical Chemistry
- Vol. 68 (13) , 2097-2101
- https://doi.org/10.1021/ac960039f
Abstract
Charge exchange ionization in conjunction with membrane introduction mass spectrometry provides a sensitive method for the detection of polar volatile organic compounds and semivolatile compounds in air. Sample introduction into an ion trap mass spectrometer was accomplished with a hollow fiber silicone membrane assembly. Atmospheric oxygen, which diffuses through the membrane, was used as the charge exchange reagent. Chemical ionization parameters were optimized using methyl ethyl ketone (2-butanone) standards in air. Several other oxygen-containing compounds, including acetone (2-propanone), methyl isobutyl ketone (4-methyl-2-pentanone), propanal, isopropyl alcohol (2-propanol), cyclohexanol, dimethyl sulfoxide (sulfinylbismethane), 2-(diethylamino)ethanol, and dimethyl methylphosphonate were analyzed with this technique. This method was used to obtain mass spectra for a variety of classes of compounds and produced a 4−20-fold improvement in response for all of the polar compounds we examined when compared to signal obtained from electron ionization.Keywords
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