OROTIC ACID AND ITS ANALOGUES: PART II. ON THE ALKALINE REARRANGEMENT OF 5-CARBOXYMETHYLIDENEHYDANTOIN
- 1 August 1960
- journal article
- research article
- Published by Canadian Science Publishing in Canadian Journal of Chemistry
- Vol. 38 (8) , 1255-1260
- https://doi.org/10.1139/v60-178
Abstract
The in vitro conversion of 5-carboxymethylidenehydantoin to orotic acid is not likely to occur in vivo since the two substances have antagonistic effects (2). A sulphur analogue of the above hydantoin has been prepared and shown not to undergo alkaline rearrangement to the corresponding metathiazine structure. The mechanism of orotic acid formation is discussed.This publication has 12 references indexed in Scilit:
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