Interspecies communication in bacteria
Open Access
- 1 November 2003
- journal article
- Published by American Society for Clinical Investigation in Journal of Clinical Investigation
- Vol. 112 (9) , 1291-1299
- https://doi.org/10.1172/jci200320195
Abstract
Until recently, bacteria were considered to live rather asocial, reclusive lives. New research shows that, in fact, bacteria have elaborate chemical signaling systems that enable them to communicate within and between species. One signal, termed AI-2, appears to be universal and facilitates interspecies communication. Many processes, including virulence factor production, biofilm formation, and motility, are controlled by AI-2. Strategies that interfere with communication in bacteria are being explored in the biotechnology industry with the aim of developing novel antimicrobials. AI-2 is a particularly attractive candidate for such studies because of its widespread use in the microbial kingdom.Keywords
This publication has 63 references indexed in Scilit:
- Mutation ofluxSAffects Biofilm Formation inStreptococcus mutansInfection and Immunity, 2003
- LuxS-Based Signaling inStreptococcus gordonii: Autoinducer 2 Controls Carbohydrate Metabolism and Biofilm Formation withPorphyromonas gingivalisJournal of Bacteriology, 2003
- Identification, Characterization, and Regulation of a Cluster of Genes Involved in Carbapenem Biosynthesis in Photorhabdus luminescensApplied and Environmental Microbiology, 2002
- Role ofNeisseria meningitidis luxSin Cell-to-Cell Signaling and Bacteremic InfectionInfection and Immunity, 2002
- Structural identification of a bacterial quorum-sensing signal containing boronNature, 2002
- Quorum Sensing in BacteriaAnnual Review of Microbiology, 2001
- Drosophila Rhomboid-1 Defines a Family of Putative Intramembrane Serine ProteasesCell, 2001
- Quorum Sensing Is a Global Regulatory Mechanism in Enterohemorrhagic Escherichia coli O157:H7Journal of Bacteriology, 2001
- The LuxS family of bacterial autoinducers: biosynthesis of a novel quorum‐sensing signal moleculeMolecular Microbiology, 2001
- The languages of bacteriaGenes & Development, 2001