Effect of Pentobarbital and Chloralose Anesthesia on Renal Function During Solute Diuresis in the Dog

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Abstract
In dogs undergoing mannitol diuresis, anesthetization with chloralose caused no change in glomerular filtration rate while pentobarbital caused a transient reduction. Urine osmolarity was not affected by either anesthetic in hydropenic animals; in hydrated animals urine osmolarity rose after giving pentobarbital. Urine Na content, expressed as a percentage of total urinary solutes, fell and remained at low levels after giving chloralose, while after pentobarbital, there was an immediate reduction followed by a rise to levels greater than observed in control experiments. In hydrated animals receiving pentobarbital, urine Na content also rose significantly. Both anesthetics caused a diminution in urine K content. After denervation of the kidneys by pedicle stripping, the response to pentobarbital administration did not differ from that of intact animals.

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