HEMAGGLUTINATING VIRUS ISOLATED FROM CAT SCRATCH DISEASE

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Abstract
A virus has been demonstrated by hemagglutination of rabbit and rat red cells in allantoic fluids from chick embryos inoculated with pus from 3 human cases of cat scratch disease. An inhibitor was present in these fluids which prevented the demonstration and was inactivated or removed by treatment of the fluids with 0.28 M glucose. Another inhibitor was present in all rabbit sera so far examined, and in most human sera which was removed by acetone and hydrochloric acid. Hemagglutinin-inhibiting antibody was demonstrated in antisera to the agent; in sera of some human cases of the disease; and in antiserum to herpes simplex virus, after treatment to remove inhibitor. Allantoic fluid inhibitor also masked the antigenicity of the virus in rabbits. The virus is antigenically related to herpes simplex but even after passage was not virulent for chick embryos; was not cytopathogenic in tissue cultures; and did not produce lesions after inoculation on to rabbit cornea.