NUCLEOPHILIC ADDITION REACTIONS ON 3-CARBETHOXY- 5,7-DIMETHOXYCOUMARIN
- 1 January 2002
- journal article
- Published by Taylor & Francis in Synthetic Communications
- Vol. 32 (5) , 679-688
- https://doi.org/10.1081/scc-120002505
Abstract
3-Carbethoxy-5,7-dimethoxycoumarin (2) underwent Michael addition and addition–cyclization of some active methylene compounds under different reaction conditions to give the adducts (3–7). Addition of phenylmagnesium bromide onto (2) yielded the tertiary alcohol (8). Addition of ammonia derivatives on (2) afforded the 3-carboxamides (9a–c) and azine (10). Furthermore, alcoholysis and hydrolysis yielded the coumarins (11a–c).Keywords
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