Inhibition of the Ca2v+‐activated K+‐channel by sapecin B, an insect antibacterial protein
Open Access
- 14 February 1994
- journal article
- research article
- Published by Wiley in FEBS Letters
- Vol. 339 (1-2) , 59-62
- https://doi.org/10.1016/0014-5793(94)80384-6
Abstract
Sapecin is an antibacterial protein of the flesh fly and sapecin B is its homologue structurally similar to charybdotoxin of scorpion venom, which is known to be a K+ channel inhibitor. We found that, like charybdotoxin, sapecin B inhibits part of the voltage pulse‐induced K+ currents of rat cerebellar Purkinje cells. We suggest that this effect is due to inhibition of the Ca+‐activated K+ channel. Probably, sapecin B is a naturally occurring K+ channel inhibitor as well as an antibacterial protein.Keywords
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