Consequences of knocking out BMP signaling in the mouse
- 3 December 2002
- Vol. 35 (1) , 43-56
- https://doi.org/10.1002/gene.10167
Abstract
Summary: During the past two decades, a significant amount of data has been accumulated revealing the intriguing functions of bone morphogenetic proteins (BMPs) in all aspects of embryonic development and organogenesis. Numerous genes encoding BMPs, BMP receptors, and their downstream signal transducers have been mutated in the mouse through targeted mutagenesis. This review focuses on what is known about the role of BMP signaling in gastrulation, mesoderm formation, left–right asymmetry, neural patterning, skeletal and limb development, organogenesis, and gametogenesis as revealed by BMP‐signaling mutants. genesis 35:43–56, 2003.Keywords
This publication has 164 references indexed in Scilit:
- Conditional inactivation of the TGF‐β type II receptor using Cre:LoxGenesis, 2002
- Diffusion of Nodal Signaling Activity in the Absence of the Feedback Inhibitor Lefty2Developmental Cell, 2001
- Haploinsufficient Phenotypes inBmp4Heterozygous Null Mice and Modification by Mutations inGli3andAlx4Developmental Biology, 1997
- Relationship between asymmetric nodal expression and the direction of embryonic turningNature, 1996
- Induction of epidermis and inhibition of neural fate by Bmp-4Nature, 1995
- Functional analysis of activins during mammalian developmentNature, 1995
- Mechanism of activation of the TGF-β receptorNature, 1994
- Limb alterations in brachypodism mice due to mutations in a new member of the TGFβ-superfamilyNature, 1994
- Follistatin, an antagonist of activin, is expressed in the Spemann organizer and displays direct neuralizing activityCell, 1994
- Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory diseaseNature, 1992