Effects of Change in Posture and of Sodium Depletion on Plasma Levels of Vasopressin and Renin in Normal Human Subjects1

Publisher Website
Google Scholar
Abstract
A study was conducted of the effects of posture and of sodium depletion on the plasma concentration of vasopressin (ADH) and the plasma renin activity (PRA) in normal human subjects. Measurements were made while the subjects were in bed after 8 hr of water deprivation, and then after a 4-hr period of ambulation. These studies were first performed while the subjects were on a normal sodium intake and again, when they were depleted of sodium. During the period of ambulation, the subjects performed their normal daily tasks, but continued to abstain from food and water. Ambulation, sodium depletion or a combination of these two procedures were without effect on the plasma ADH concentration. PRA, on the other hand, was increased by both ambulation and sodium depletion. It is suggested that under the conditions of these experiments, the renin-angiotensin system does not play a significant role in the control of the release of ADH.

This publication has 0 references indexed in Scilit: