Preparations, solution conformations and molecular structures of N,N′‐ethylene‐bridged dipeptides and their derivatives
- 1 June 1991
- journal article
- Published by Wiley in International Journal of Peptide and Protein Research
- Vol. 37 (6) , 468-475
- https://doi.org/10.1111/j.1399-3011.1991.tb00763.x
Abstract
The solution conformations of novel dipeptides, methyl (2S, 3′S)-3-methyl-2-(2′-oxo-3′-isopropyl-1′-piperazinyl)-butanoate (EVV-OCH3), methyl (2S, 3′S)-3-phenyl-2-(2′-oxo-3′-benzyl-1′-piperazinyl) propionate (EFF-OCH3), and their derivatives (Boc-Gly-EW-OH, Boc-Gly-EVV-Gly-OH, and Boc-Gly-EFF-OH), were studied by ‘H NMR measurements and molecular mechanics calculations (1). The molecular structures of Boc-Gly-EVV-OH, Boc-Gly-EFF-OH, and the hydrochloride of EVV-OCH3 were determined by X-ray analyses. The conformations of the piperazinone rings and the side chains of these oligopeptides were clarified.Keywords
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