FIBRIN FORMATION - EFFECT OF CALCIUM-IONS

  • 1 January 1978
    • journal article
    • research article
    • Vol. 52  (4) , 654-658
Abstract
Using laser fluctuation spectroscopy, a technique that measures particle size change in solution, the kinetics of fibrin clot formation from [human] fibrinogen could be studied. With this technique the effect of Ca2+ on the 3 distinguishable phases of clot formation, proteolysis of fibrinogen, fibrinogen-fibrin monomer complex formation and fibrin monomer polymerization were investigated. Only a small change in the length of the induction period that results from the fibrinogen-fibrin monomer interactions was observed. There was a marked increase in the rate of fibrin monomer polymerization in the presence of Ca2+ ions. Ca2: decreases the time required for fibrin formation from fibrinogens by markedly accelerating the phase of fibrin monomer polymerization.