Progress in Colon Cancer -- Do Molecular Markers Matter?

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Abstract
All cancer staging systems seek to identify clinical and pathologic features that can predict outcome (prognosis) or in some cases guide therapy. The theme common to all staging systems for colorectal carcinoma is that the depth of invasion of the bowel wall and the presence or absence of lymph-node involvement are powerful predictors of whether or not the cancer will recur. Other prognostic features, such as sex, tumor site within the colon, tumor grade, and the degree of local invasion, perforation, or obstruction,1 which may not appear in pathologic staging systems, are often used as stratification factors in the design . . .