Acute pulmonary toxicity of inhaledβ-1,3-glucan and endotoxin
- 1 January 1992
- journal article
- inflammation and-immunomodulation
- Published by Springer Nature in Inflammation Research
- Vol. 35 (1-2) , 50-56
- https://doi.org/10.1007/bf01990951
Abstract
The number of inflammatory cells was studied in lung walls and airways after inhalation of endotoxin or β-1,3-glucan. In the water unsoluble form, β-1,3-glucan caused a delayed response in terms of a decrease in macrophages and lymphocytes in the lung wall, 1 to 7 days after exposure but no invasion of neutrophils into the airways. When solubilized in 0.02 N NaOH, the cell response was the same as that observed after exposure to endotoxin.Keywords
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