Expression of serine/threonine kinase receptors in traumatic brain injury
- 1 January 1997
- journal article
- Published by Wolters Kluwer Health in NeuroReport
- Vol. 8 (2) , 475-479
- https://doi.org/10.1097/00001756-199701200-00020
Abstract
The aim of this study was to investigate the expression of serine/threonine kinase receptors in the brain following traumatic brain injury. We report here that, the recently cloned and characterized bone morphogenetic protein (BMP) receptor type II (BMPR-II) and the activin receptor type IA (ActR-1) Act: mRNAs were simultaneously up-regulated in neurones in the dentate gyrus 6 h after a mild cerebral contusion injury. This findings was specific for these receptors since other investigated genes (i.e. ActR-II, ActR-IB, trkB and c-fos) showed other temporal patterns. These data suggest that type I and type II receptors act together in signal transduction in vivo and that BMPs may be involved in neuronal plasticity after traumatic brain injury.Keywords
This publication has 8 references indexed in Scilit:
- TGFβ Signaling: Receptors, Transducers, and Mad ProteinsCell, 1996
- Expression of activin receptors type I and II only partially overlaps in the nervous systemNeuroReport, 1995
- Cloning of a Novel Type II Serine/Threonine Kinase Receptor through Interaction with the Type I Transforming Growth Factor-β ReceptorJournal of Biological Chemistry, 1995
- Pattern formation in the visual centers of the Drosophila brain: wingless acts via decapentaplegic to specify the dorsoventral axisCell, 1994
- The TGF-β family and its composite receptorsTrends in Cell Biology, 1994
- The DVR gene family in embryonic developmentTrends in Genetics, 1991
- Expression cloning of an activin receptor, a predicted transmembrane serine kinaseCell, 1991
- Expression of growth/differentiation factor 1 in the nervous system: conservation of a bicistronic structure.Proceedings of the National Academy of Sciences, 1991