Pigmented Hyperplasia of Epidermis Following Feeding of l -Dopa to Elderly Rats
- 1 May 1977
- journal article
- research article
- Published by Oxford University Press (OUP) in JNCI Journal of the National Cancer Institute
- Vol. 58 (5) , 1433-1436
- https://doi.org/10.1093/jnci/58.5.1433
Abstract
In view of clinical data supporting a causal relationship between long-term l-dopa administration and recurrence of melanoma, long-term l-dopa administration to aged rats was performed to investigate its effect on the incidence of malignant melanoma. Of the treated animals, 11% showed local pigmented epidermal hyperplasia, compared with 0.5% of the control animals, but the number of expected melanomas was not increased by l-dopa treatment.Keywords
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