MicroRNAs Modulate Hematopoietic Lineage Differentiation
Top Cited Papers
- 2 January 2004
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 303 (5654) , 83-86
- https://doi.org/10.1126/science.1091903
Abstract
MicroRNAs (miRNAs) are an abundant class of ∼22-nucleotide regulatory RNAs found in plants and animals. Some miRNAs of plants, Caenorhabditis elegans , and Drosophila play important gene-regulatory roles during development by pairing to target mRNAs to specify posttranscriptional repression of these messages. We identify three miRNAs that are specifically expressed in hematopoietic cells and show that their expression is dynamically regulated during early hematopoiesis and lineage commitment. One of these miRNAs, miR-181, was preferentially expressed in the B-lymphoid cells of mouse bone marrow, and its ectopic expression in hematopoietic stem/progenitor cells led to an increased fraction of B-lineage cells in both tissue-culture differentiation assays and adult mice. Our results indicate that microRNAs are components of the molecular circuitry that controls mouse hematopoiesis and suggest that other microRNAs have similar regulatory roles during other facets of vertebrate development.Keywords
This publication has 26 references indexed in Scilit:
- The nuclear RNase III Drosha initiates microRNA processingNature, 2003
- Control of leaf morphogenesis by microRNAsNature, 2003
- RETRACTED ARTICLE: Hes1 is a target of microRNA-23 during retinoic-acid-induced neuronal differentiation of NT2 cellsNature, 2003
- MicroRNAs and Other Tiny Endogenous RNAs in C. elegansCurrent Biology, 2003
- The microRNAs ofCaenorhabditis elegansGenes & Development, 2003
- The Drosophila MicroRNA Mir-14 Suppresses Cell Death and Is Required for Normal Fat MetabolismCurrent Biology, 2003
- Sequence requirements for micro RNA processing and function in human cellsRNA, 2003
- An Abundant Class of Tiny RNAs with Probable Regulatory Roles in Caenorhabditis elegansScience, 2001
- Identification of Novel Genes Coding for Small Expressed RNAsScience, 2001
- The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14Cell, 1993