Chemical studies on tuberactinomycin. XV. Total synthesis of tuberactinomycin O.
- 1 January 1977
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 30 (12) , 1073-1079
- https://doi.org/10.7164/antibiotics.30.1073
Abstract
Tuberactinomycin O, 1 of the 4 congeners of the antituberculous peptide tuberactinomycin, was totally synthesized. The .beta.-ureidodehydroalanine moiety was constructed from .beta.,.beta.-diethoxyalanine with excess urea in acidic medium after a cyclization reaction of a pentapeptide was finished. Cyclization was carried out by means of the 1-succinimidyl ester method. To the cyclic pentapeptide, .beta.-lysine was introduced as the branched moiety and then deprotected to afford tuberactinomycin O which was completely identified with the natural form of the antibiotic.This publication has 0 references indexed in Scilit: