Activity of Rifabutin Alone or in Combination with Clofazimine or Ethambutol or Both Against Acute and Chronic ExperimentalMycobacterium intracellulareInfections
- 1 August 1987
- journal article
- research article
- Published by American Thoracic Society in American Review of Respiratory Disease
- Vol. 136 (2) , 329-333
- https://doi.org/10.1164/ajrccm/136.2.329
Abstract
Rifabutin (ansamycin LM 427) when given alone in doses of 5,10, or 20 mg/kg showed limited in vivo activity against acute or chronic Mycobacterium intracellulare infections studied in beige C57B1/6, or S/W mice. Prophylactic studies in S/W mice in which chemotherapy was given for 3 wk prior to challenge showed slight improvement. Combination chemotherapy consisting of rifabutin (10 mg/kg) and clofazimine (20 mg/kg) achieved complete sterilization of M. Intracellulare infections in spleen and lung when initiated immediately after challenge. Inclusion of ethambutol did not offer additional benefit. If chemotherapy is initiated 3 wk after challenge (established infections), the activity of this double drug combination is less effective.This publication has 1 reference indexed in Scilit:
- Determination of ansamycin MICs for Mycobacterium avium complex in liquid medium by radiometric and conventional methodsAntimicrobial Agents and Chemotherapy, 1985