Human Hypersensitiveness to Whole Horse Serum or Serum Globulins Following Diphtheria Toxin-Antitoxin Injections—Its Importance

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Abstract
This preliminary communication is made at this time because of the interest aroused by Hooker's communication at the December meeting of the Society of American Bacteriologists. He observed that a considerable percentage of adults who had some months previously received three injections of diphtheria toxin-antitoxin (3 L plus preparation) developed a skin sensitiveness to horse serum. Two series of observations are here presented, one on children, the other on adults which confirm Hooker's conclusion, that a specific skin hypersensitiveness may be induced, in a moderate percentage of children and adults by the injection of the minute amount of horse serum globulins contained in the toxin-antitoxin injections. The results of tests on untreated persons and on those who had received larger amounts of serum globulins are also given as a comparison. As the antitoxin globulin solution is universally used to supply the antitoxin in the toxin-antitoxin, the globulin solution is used as the testing substances in most cases.

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