Methiodide of the GABA antagonist (+)‐bicuculline is levorotatory
- 1 January 1989
- Vol. 1 (2) , 178-179
- https://doi.org/10.1002/chir.530010214
Abstract
The appearance of positive charge on the nitrogen moiety of phthalideisoquinoline alkaloids brings about a strong change in the intensities of CD Cotton effects. Hence the optical rotations of enantiomeric salts and their parent base of identical configuration are often of opposite sign. Thus, the name (+)‐bicuculline‐methiodide for the methiodide salt of (+)‐bicuculline is false.Keywords
This publication has 13 references indexed in Scilit:
- Inhibition of [3H]GABA binding to rat brain synaptic membranes by bicuculline related alkaloidsBiochemical Pharmacology, 1984
- [3H]Bicuculline Methochloride Binding to Low‐Affinity γ‐Aminobutyric Acid Receptor SitesJournal of Neurochemistry, 1983
- The NMR Spectra and Conformations of the PhthalideisoquinolinesJournal of Natural Products, 1982
- The Phthalideisoquinoline AlkaloidsJournal of Natural Products, 1982
- GABA receptor binding with 3H (+) bicuculline–methiodide in rat CNSNature, 1977
- (+) and (−)-bicuculline methochloride as optical isomers of a GABA antagonistNature, 1974
- Bicuculline Methochloride as a GABA AntagonistNature New Biology, 1972
- GABA, Bicuculline and Central InhibitionNature, 1970
- The optical rotatory dispersion and circular dichroism of the phthalideisoquinoline alkaloids and of their α-hydroxybenzyltetrahydroisoquinoline derivativesTetrahedron, 1969
- Zur Konfiguration stickstoffhaltiger Verbindungen XVIII. Bestimmung der relativen und absoluten Konfiguration der Phthalidisochinolin-AlkaloideCollection of Czechoslovak Chemical Communications, 1964