EFFECT OF EPINEPHRINE ON PLASMA LIPID COMPONENTS AND INTERRELATIONSHIPS IN NORMAL AND EPILEPTIC HUMANS

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Abstract
Measurements were made of the plasma lipid components in postabsorptive normal and epileptic individuals without previous treatment, and 60 minutes after 0.4 mg of epinephrine were given intramuscularly. There was no difference between the normal group and the epileptic group with respect to concentrations of total lipids or the several lipid fractions previous to treatment, but there was a significant difference regarding ratios total cholesterol/lipid-phosphorus and phospholipid/free cholesterol. After epinephrine injection the neutral fat fraction in normal subjects was significantly increased, whereas after similar treatment of the epileptics there was significant increase in concentration of phospholipids. Due to differences between normal and epileptic groups in response to epinephrine administration there were several significant alterations in interrelationships of certain lipid fractions.