A Comparative Clinical Trial of Mianserin (Norval®) and Amitriptyline in the Treatment of Depression in General Practice
- 1 May 1978
- journal article
- research article
- Published by SAGE Publications in Journal of International Medical Research
- Vol. 6 (3) , 199-206
- https://doi.org/10.1177/030006057800600306
Abstract
A double-blind controlled comparative trial of mianserin (Norval®) and amitriptyline was conducted in general practice. Fifty-one patients were treated with amitriptyline and fifty-five with mianserin. The dosage for the first week was 25 mg t.d.s. for amitriptyline and 10 mg t.d.s. for mianserin, increasing to 50 mg t.d.s. and 20 mg t.d.s. respectively for the subsequent three weeks. Both drugs proved equally effective in relieving the symptoms of primary depression but mianserin showed a reduced incidence of side-effects which was statistically significant.This publication has 8 references indexed in Scilit:
- Mianserin: a decade of scientific development.British Journal of Clinical Pharmacology, 1978
- Mianserin in the treatment of depressive illness and anxiety states in general practice.British Journal of Clinical Pharmacology, 1978
- Choosing an antidepressant.BMJ, 1978
- The effect of a tetracyclic antidepressant compound, Org GB94, on the turnover of biogenic amines in rat brainBiochemical Pharmacology, 1976
- Mianserin Hydrochloride: A Novel AntidepressantThe British Journal of Psychiatry, 1976
- Mianserin versus AmitriptylineInternational Pharmacopsychiatry, 1976
- Autonomic actions and interactions of mianserin hydrochloride (Org. GB 94) and amitriptyline in patients with depressive illnessPsychopharmacology, 1976
- A Comparative Clinical Trial of Org GB 94 and Imipramine in the Treatment of Depression in General PracticeJournal of International Medical Research, 1975