THE EFFECTS OF IODIDE, PERCHLORATE, THIOCYANATE,AND NITRATE ADMINISTRATION UPON THEIODIDE CONCENTRATING MECHANISMOF THE RAT THYROID*

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Abstract
The thyroid gland of an animal chronically treated with a thiouracillike drug, although unable to manufacture thyroid hormone, manifests a remarkable ability to collect and concentrate the iodide ion (Vanderlaan and Vanderlaan, 1947; Taurog, Chaikoff, and Feller, 1947). About one hour after the subcutaneous administration of iodide in rats the thyroid exhibits an average concentration gradient of 250 over the serum. Taurog, Chaikoff, and Feller (1947) noted this ratio to be unchanged when 2 μg. or 100 μg. of iodide were given to adult rats. Vanderlaan and Vanderlaan (1947) found that the gradieni, remained constant when doses up to 100 ng. of potassium iodide were administered in young rats, but that when larger quantities were given it diminished progressively. However, even when 10,000 μg. were given the. gradient was not abolished completely, a concentration of 3 fold persisting in favor of the gland.