Adaptation of HIV‐1 to pigtailed macaques

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Abstract
In vitro infectivity experiments were performed to assess the susceptibility of cells from various monkey species to HIV‐1. T lymphocytes from pig‐tailed macaques, but not those from rhesus or cynomolgus monkeys, were susceptible to infection, but virus expression was limited. The majority of HIV‐1 isolates were unable to productively infect pigtailed macaque cells. Inoculation of autologous, HIV‐1 expressing cells led to establishment of persistent infection in pigtailed macaques as evidenced by recovery of infectious virus and development of virus‐specific antibody responses.