FIBRINOGEN CONCENTRATION IN ACUTE MYOCARDIAL INFARCTION
- 1 February 1954
- journal article
- research article
- Published by American Medical Association (AMA) in A.M.A. Archives of Internal Medicine
- Vol. 93 (2) , 231-245
- https://doi.org/10.1001/archinte.1954.00240260067006
Abstract
THE ERYTHROCYTE sedimentation rate (ESR) is commonly employed for the clinical evaluation of acute myocardial infarction.* Ever since the ESR was introduced into medical practice by Fahraeus, in 1921,13it has been known that the fibrinogen concentration of the plasma is of foremost significance in the production of rapid settling of the red blood cells. Frequently, however, secondary factors influence the suspension stability of the blood, such as the various globulins,† cholesterol,17the viscosity of the plasma,‡ the size of the red blood cells,‡ the volume of packed red cells,§ and the electrostatic charge of the proteins and the red blood cells.16It is obvious, therefore, that a method which depends on a great number of factors is bound to produce bizarre results even under the most carefully controlled conditions and even when a standardized technique is used. Thus, a method would offer a distinct clinical advantage if it wereThis publication has 0 references indexed in Scilit: