Expression of interleukin‐1α and interleukin‐1 receptor type I genes in murine brown adipose tissue

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Abstract
At thermoneutral conditions, high steady‐state levels of transcripts for both IL‐1α and its receptor IL‐1RtI were found in specialized thermogenic organ, brown adipose tissue (BAT) of adult mice, as compared with the levels in lymph nodes, brain and spleen. A pronounced decrease of IL‐1α mRNA level in BAT was observed after lipopolysaccharide (LPS) administration and after exposure to cold. Likewise, LPS decreased the IL‐1 RtI mRNA level and depressed also the expression of cold‐inducible genes for the BAT‐specific heat‐producing uncoupling protein and for lipoprotein lipase. It is concluded that, besides the centrally‐mediated effects, there exists a direct peripheral interaction of IL‐1 cytokines with BAT cells.