RENAL EXCRETION OF PSEUDOEPHEDRINE IN THE RAT

  • 1 January 1979
    • journal article
    • research article
    • Vol. 211  (3) , 555-560
Abstract
Pseudoephedrine, is an organic base used in the treatment of upper respiratory tract disorders. Surgical techniques and experimental procedures were developed to study the renal elimination mechanisms for this drug in the rat. The ability to measure renal clearance accurately and to demonstrate renal secretion by a carrier-mediated transport system was verified by comparing results from N1-methylnicotinamide (NMN) excretion studies with literature results. Renal tubular secretion of NMN was saturable and was inhibited by mepiperphenidol to the same extent as previously reported. Pseudoephedrine was cleared by the kidney at a rate in excess of inulin and close to or possibly greater than renal plasma flow. In addition to filtration and secretion, pseudoephedrine appeared to be subject to pH dependent passive reabsorption. When the secretion of pseudoephedrine was studied in detail, it was nonsaturable for plasma levels of pseudoephedrine ranging from 0.16-1.5 .mu.g/ml. Secretion was inhibited by mepiperphenidol suggesting a carrier-mediated process.

This publication has 0 references indexed in Scilit: