Should the Asymmetry of Enzymatic Active Centers Always Correlate with the Asymmetry of their Substrates?
- 1 October 1996
- journal article
- research article
- Published by Taylor & Francis in Journal of Biomolecular Structure and Dynamics
- Vol. 14 (2) , 225-230
- https://doi.org/10.1080/07391102.1996.10508111
Abstract
Analysis of the substrate specificity of DNA polymerases and in part some other enzymes of nucleic acid metabolism towards unnatural L-stereomeric nucleosides and nucleotides was made. As a result, the hypothesis is proposed that when the chiral part of the substrate molecule does not interact specifically with the enzyme, substitution of natural D enantiomers by L compounds is possible.Keywords
This publication has 25 references indexed in Scilit:
- L- and D-Enantiomers of 2′,3′-Dideoxycytidine 5′-Triphosphate Analogs as Substrates for Human DNA PolymerasesJournal of Biological Chemistry, 1995
- Does Interaction of dNTP Glycone with an Active Center of Reverse Transcriptases Takes Place? A Model for a Binding SiteNucleosides, Nucleotides and Nucleic Acids, 1995
- Polymerase Structures and MechanismScience, 1994
- Selectivity of DNA polymerases toward α and β nucleotide substrates ofdandlseriesFEBS Letters, 1994
- Novel Acyclic Nucleotides and Nucleoside 5'-Triphosphates Imitating 2',3'-Dideoxy-2',3'-didehydro nucleotides: Synthesis and Biological PropertiesJournal of Medicinal Chemistry, 1994
- Chiral Discrimination of Enantiomeric 2′-Deoxythymidine 5′-Triphosphate by HIV-1 Reverse Transcriptase and Eukaryotic DNA PolymerasesBiochemical and Biophysical Research Communications, 1994
- Acyclic 2′, 3′-Dideoxy-2′,3′-didehydronucleoside 5′-Triphosphates as Termination Substrates of Broad Set of DNA PolymerasesNucleosides and Nucleotides, 1993
- The potential of carbocyclic nucleosides for the treatment of AIDS: synthesis of some diphosphorylphosphonates possessing potent activity against HIV-coded reverse transcriptaseJournal of the Chemical Society, Perkin Transactions 1, 1992
- Preparation of the geometric isomers of DDC, DDA, D4C and D4T as potential anti-HIV agentsBioorganic & Medicinal Chemistry Letters, 1991
- Selective Inhibition of DNA Chain Elongation Catalyzed by DNA PolymerasesNucleosides and Nucleotides, 1988