Association of Glucocerebrosidase Mutations With Dementia With Lewy Bodies
Open Access
- 1 May 2009
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Neurology
- Vol. 66 (5) , 578-583
- https://doi.org/10.1001/archneurol.2009.54
Abstract
Lewy body (LB) disorders include Parkinson disease (PD), dementia with LBs (DLB), and LB variant of Alzheimer disease (LBV-AD). They have in common pathologically the presence of aberrant intracellular α-synuclein aggregates (LBs and Lewy neurites). Clinically, these disorders tend to have symptoms of parkinsonism and dementia.1,2 It is common for Alzheimer disease (AD) and LB disorders to overlap; both may occur in the same brain (eg, LBV-AD).Keywords
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