Synthesis and biological activities of a tetradecapeptide renin substrate

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Abstract
The synthesis of a tetradecapeptide renin substrate is described. This compound has the structure of val5-angiotensin I-amide with four additional amino acids on the carboxyl end. The tetradecapeptide has a pressor activity in nephrectomized rats and rabbits which differs qualitatively and quantitatively from the pressor action of angiotensin n-amide. The tetradecapeptide also causes the contraction of isolated smooth muscle preparations and is rapidly degraded in plasma of both intact and nephrectomized rats.

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