Enantioselective Sulfide Oxidation with H2O2: A Solid Phase and Array Approach for the Optimisation of Chiral Schiff Base-Vanadium Catalysts
- 1 July 2002
- journal article
- letter
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 2002 (07) , 1055-1060
- https://doi.org/10.1055/s-2002-32582
Abstract
Two libraries of chiral Schiff base ligands were synthesised and screened in the vanadium-catalysed oxidation of alkyl aryl sulfides with hydrogen peroxide as terminal oxidant. The vanadium-chiral Schiff base complex 10, readily prepared from 3,5-diiodo-salicylaldehyde and (S)-tert-leucinol, was found to be highly enantioselective. Optically active sulfoxides could thus be obtained in good yields with up to 97% ee.Keywords
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