Persistent infections in salmonid fish cells with infectious pancreatic necrosis virus (IPNV)*
- 1 October 1978
- journal article
- Published by Wiley in Journal of Fish Diseases
- Vol. 1 (4) , 297-308
- https://doi.org/10.1111/j.1365-2761.1978.tb00034.x
Abstract
Two cell lines that are persistently infected with IPN virus have been established. Viral persistence in the cultures was demonstrated by the detection of infectious virus (102‐105,5 TCID/ml50) in the culture fluids, by specific immunofluorescence, and by their resistance to superinfection by homologous virus. The growth, rate of these cells was indistinguishable from normal, uninfected cells. Virus stocks harvested from persistently infected cultures contained a greater proportion of defective, interfering particles than those from lytically infected cells which suggests that these particles may be responsible for the maintenance of these carrier cultures.Keywords
This publication has 24 references indexed in Scilit:
- The Structure of Infectious Pancreatic Necrosis Virus RNAJournal of General Virology, 1977
- Persistent infection of tissue culture cells by RNA virusesMedical Microbiology and Immunology, 1976
- An antigenic comparison of three strains of infectious pancreatic necrosis virus of salmonid fishesAquaculture, 1975
- Possible Interference in the Isolation of IPN Virus from Carrier FishJournal of the Fisheries Research Board of Canada, 1975
- Frequency of Detection and Survival of Infectious Pancreatic Necrosis Virus in a Carrier Population of Brook Trout (Salvelinus fontinalis) in a LakeJournal of the Fisheries Research Board of Canada, 1975
- Persistent Noncytocidal Vesicular Stomatitis Virus Infections Mediated by Defective T Particles that Suppress Virion TranscriptaseProceedings of the National Academy of Sciences, 1974
- Cyclic Production of Vesicular Stomatitis Virus Caused by Defective Interfering ParticlesThe Journal of Infectious Diseases, 1974
- Defective Viral Particles and Viral Disease ProcessesNature, 1970
- Quantitative Comparison of Peritoneal Washes and Feces for Detecting Infectious Pancreatic Necrosis (IPN) Virus in Carrier Brook TroutJournal of the Fisheries Research Board of Canada, 1969
- THE IN VITRO CULTIVATION OF TISSUE AND CELLS OF PACIFIC SALMON AND STEELHEAD TROUT*Annals of the New York Academy of Sciences, 1965