Two Bioactive Saponins from Albizia subdimidiata from the Suriname Rainforest
- 29 March 2001
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Natural Products
- Vol. 64 (4) , 536-539
- https://doi.org/10.1021/np000295u
Abstract
Bioassay-guided fractionation of a methanol extract of Albizia subdimidiata using the engineered yeast strains 1138, 1140, 1353, and Sc7 of Saccharomyces cerevisiae as the bioassay tool resulted in the isolation of the two active saponins 1 and 2; one of these, albiziatrioside A (1), is described for the first time. The structures of 1 and 2 were established on the basis of HRMS, 1D and 2D NMR spectral data, and GC−MS analysis of the sugar units. Both isolated compounds showed significant cytotoxicity against the A2780 cell line.Keywords
This publication has 8 references indexed in Scilit:
- Kinmoonosides A−C, Three New Cytotoxic Saponins from the Fruits of Acacia concinna, a Medicinal Plant Collected in MyanmarJournal of Natural Products, 2000
- Rakicidins, New Cytotoxic Lipopeptides from Micromonospora sp. Fermentation, Isolation and Characterization.The Journal of Antibiotics, 1995
- An improved methylation procedure for the analysis of complex polysaccharides including resistant starch and a critique of the factors which lead to undermethylationPhytochemical Analysis, 1993
- Saponins from Albizzia lucidaPhytochemistry, 1991
- New Triterpenoid N‐Acetylglycosides with Molluscicidal Activity from Tetrapleura tetraptera TAUBHelvetica Chimica Acta, 1989
- Saponins from Albizzia anthelminticaPhytochemistry, 1989
- Gas-liquid chromatographic separation of aldose enantiomers as trimethylsilyl ethers of methyl 2-(polyhydroxyalkyl)-thiazolidine-4(R)-carboxylates.CHEMICAL & PHARMACEUTICAL BULLETIN, 1987
- A triterpenoid glycoside from Tetrapleura tetraptera fruitPhytochemistry, 1985