Drug substitution and rational therapeutics

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Abstract
Prescriptions written by physicians are nearly always filled with a drug of the same chemical entity and same strength as the drug prescribed. But now a relatively new practice—therapeutic substitution—allows nonphysicians to substitute another drug for the one prescribed by the examining physician. Dr Nelson reviews this concept, as well as other common methods of drug substitution, and explains why therapeutic substitution represents a threat to the patient-physician relationship.

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