The Effect of Host Age on the Transplantability of the Walker 256 Carcinosarcoma

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Abstract
The effect of the age of the host on the incidence and growth rate of the Walker 256 carcinosarcoma was Investigated in five groups of male Sprague-Dawley rats ranging in age from I to 17 mo. Tumors were transplanted into the flexor muscle mass of each thigh using a standardized ascites tumor inoculum of I × 105 cells/0.1 ml. The highest incidence of tumors (100% takes) occurred in the youngest age group (35 ± 3 days). As host age increased, the incidence of tumors decreased linearly. Younger animals also showed a faster tumor growth rate as revealed in the weight of the tumors after a 7-day growth period. These results apparently are observed only when relatively low numbers of tumor cells are injected. Possible age-associated physiological changes are discussed that could account for the decreased tumor susceptibility observed in older animals.

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