Abstract
The clinical records of 32 patients with sarcoidosis associated with splenomegaly were reviewed. When compared with a matched control population without splenomegaly, patients with splenomegaly had evidence of more extensive extrathoracic sarcoidosis. In contrast, there was no difference in degree of pulmonary involvement between patients with or without splenomegaly. Of the 32 patients with splenomegaly, 7 (20%) had evidence of hypersplenism and 5 (16%) had abdominal symptoms. These abnormalities occurred only in patients with greatly enlarged spleens. Considering splenomegaly, corticosteroids apparently are indicated in the management of only large spleens and not of smaller spleens, unless there are other specific indications.

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