Proton magnetic resonance studies on the conformation of the hexanucleotide GmpApApYpApψp, and related fragments from the anticodon loop of baker's yeast phenylalanine transfer ribonucleic acid
- 15 July 1975
- journal article
- research article
- Published by American Chemical Society (ACS) in Biochemistry
- Vol. 14 (14) , 3278-3291
- https://doi.org/10.1021/bi00685a038
Abstract
A hexanucleotide, GmpApApYpAp$p, and 1 1 related compounds from the anticodon loop of Baker's yeast tRNAPhe were studied by proton magnetic resonance from 100 to 250 MHz. Totally 19 resonance lines from all the base protons (Hg, H.5, and H2), HI!, and methyl proton res- onances of the hexamer have been assigned by a systematic "incremental procedure" in comparing all the related short- er fragments. Emphasis is given to the Y base and its stack- ing conformation with respect to its nearest neighboring bases. The results reveal a strong tendency of the purineKeywords
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