Identification of Ongoing Human Immunodeficiency Virus Type 1 (HIV-1) Replication in Residual Viremia during Recombinant HIV-1 Poxvirus Immunizations in Patients with Clinically Undetectable Viral Loads on Durable Suppressive Highly Active Antiretroviral Therapy

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Abstract
In most human immunodeficiency virus type 1 (HIV-1)-infected individuals who achieve viral loads of P= 0.03) and was more likely to occur within epitopes presented by relevant HLA alleles (P< 0.001). These findings suggest that ongoing virus replication contributes to low-level viremia in patients on HAART and that this ongoing replication is subject to CD8+T-cell selective pressures.