Effects of Proximal Gastric Vagotomy on Intragastric Pressure and Adaptation in Pigs

Publisher Website
Google Scholar
Abstract
Stadaas, J., Aune, S. & Haffner, J. F. W. Effects of proximal gastric vagotomy on intragastric pressure and adaptation in pigs. Scand. J. Gastroent. 1974, 479–485. The intragastric pressure/volume relationship was studied in anaesthetized pigs with a large plastic bag placed in the stomach. Basal pressure, rhythmic activity, and adaptation time, i.e. the time required for the basal pressure to stabilize after each alteration in volume, were studied after stepwise filling and emptying of the bag. Studies were made in the normal state, after proximal gastric vagotomy (PGV) and following additional truncal vagotomy. Three pigs which served as controls were studied twice; after laparotomy and after sham operation. No difference was found between the first and second sequence in the controls, or between the recordings in the control group and the treated animals before vagal denervation, indicating that gastric motor activity was not affected by the recording procedure. After PGV, basal pressure increased significantly more with distention than before (p<0.05). There was also a significant increase in adaptation time (p<0.05) and a marked reduction of rhythmic activity. Truncal vagotomy had no additional effects on the parameters in the present series. It is concluded that PGV changes motility and adaptability of the corpus and fundus of the stomach. These changes are not influenced by additional truncal vagotomy.