The vital staining of normal and malignant cells. I.-Vital staining with trypan blue, and the cytoplasmic inclusions of liver and kidney cells

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Abstract
By the technique described, it is possible to demonstrate (a) dye droplets and mitochondria; (b) dye droplets and Golgi apparatus. No definite relationship can be established between dye droplets and mitochondria. The dye droplets make their appearance in relationship with the Golgi apparatus, and when formed break away from it into the cytoplasm. The formation of dye droplets in relationship with the Gogi apparatus resembles the process of formation of secretion granules in gland cells. Regarded in the light of recent research, the observations suggest that the following functional inter-relationship exists between the Golgi apparatus and mitochondria: At the mitochondrial-cytoplasmic surface syntheses by enzymes occur. The resulting products continually diffuse into the cytoplasm, preventing an accumulation at the surface of the mitochondria, which would inhibit further syntheses. At the surface of the Golgi apparatus the elaborated products are concentrated into droplets preliminary to their elimination.

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