Expression of Class-3 Semaphorins and Their Receptors in the Neonatal and Adult Rat Retina
Open Access
- 1 December 2004
- journal article
- Published by Association for Research in Vision and Ophthalmology (ARVO) in Investigative Opthalmology & Visual Science
- Vol. 45 (12) , 4554-4562
- https://doi.org/10.1167/iovs.04-0173
Abstract
Purpose. Semaphorins comprise a family of molecules that influence the growth and guidance of neuronal processes. Class-3 semaphorins are secreted proteins, and their effects are mediated by neuropilin (NP) and plexin (Plx) receptors. There is considerable information on mechanisms that influence axonal guidance and plasticity in the mammalian visual system, but a role for semaphorins has received less scrutiny. The purpose of the current study was to survey class-3 semaphorin and cognate receptor expression in young and adult rat retinas.Keywords
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