Hypnotic Effectiveness of Sodium Salicylamide with Short-Term Use: Sleep Laboratory Studies

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Abstract
Sodium salicylamide in doses of 650 and 1300 mg was evaluated in 2 separate sleep laboratory drug evaluation studies of insomnia patients. Each study utilized a standard protocol of 10 consecutive laboratory nights consisting of 4 placebo nights for adaptation and baseline, 3 drug nights for short-term drug administration and 3 placebo nights for evaluating withdrawal. Neither dose had a clear-cut hypnotic effect in inducing or maintaining sleep. Sleep stages were not affected by drug administration or drug withdrawal. Both the objective findings and subjective estimates suggest that the 1300 mg dose may have a slight sedative effect. When salicylamide is used as an ingredient in over-the-counter preparations, the usual dose is only 200-400 mg.