Budesonide and Nasal Histamine Challenge

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Abstract
The possible mode of action of the lately demonstrated steroid effect on the immediate type allergic reaction was investigated. The influence of a topical steroid, budesonide, on the effects that released mediators have on the nasal mucosa was also studied. A nasal histamine challenge study was performed in a double‐blind. cross‐over fashion, a 1‐weck. Pretreatment with budesonide or placebo preceding the challenge. Symptoms were recorded by means of symptom score as well as objectively via rhinomanometry.In contrast to a previous allergen challenge study, the steroid was found to have minimal effect on the histamine‐induced nasal symptoms. It is therefore concluded that other modes of steroid action must also be involved lin the steroid effect on the immediate type allergic reaction.