EXPERIMENTAL CHEMOTHERAPY OF CARCINOMA OF HUMAN STOMACH AND COLON SERIALLY TRANSPLANTED IN NUDE-MICE

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  • 1 January 1978
    • journal article
    • research article
    • Vol. 69  (3) , 299-309
Abstract
Human gastric and colon carcinomas serially transplantable in nude mice, designated as St-4, St-15 and Co-3, were used for chemotherapeutic experiments. All tumors showed a 100% take rate and stable growth. Mitomycin-C (MMC), 3 mg/kg body wt, given i.p. 4 times once weekly, showed some inhibiting effect on Co-3, St-15 and St-4 in that order. N1-(2''-Tetrahydrofuryl)-5-fluorouracil (FT-207), 90 mg/kg body wt, i.p. daily for 4 wk, suppressed the growth of Co-3 and St-15 slightly but with statistical significance, and had no effect on St-4. Co-3, a tumor with more rapid growth and richer vascular supply, was suppressed more by MMC and FT-207. These 3 transplantable tumors may be useful, not only in evaluating chemotherapeutic agents for use against human gastrointestinal carcinomas, but also for screening of new antitumor agents.

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