Highly enantioselective route to (R)-proline derivatives via enzyme catalysed hydrolysis of cis-N-benzyl-2,5-bismethoxycarbonylpyrrolidine in an aqueous dimethyl sulphoxide medium
- 1 January 1987
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 13,p. 1041-1042
- https://doi.org/10.1039/c39870001041
Abstract
Pig liver esterase catalysed hydrolysis of diester (1) with dimethyl sulphoxide as cosolvent in buffered solutions gave optically pure monoester (2) which was further transformed to the (R)-proline related ester (4) by radical decarboxylation.Keywords
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