Marfanʼs Syndrome With 47, XXX Genotype and Possible Immunologic Abnormality

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Abstract
A 2 yr old girl with Marfan''s syndrome had recurrent episodes of upper respiratory infection, otitis media, tonsillitis and asthma. Chromosomal study revealed the karyotype 47,XXX. Immunologic evaluation showed lack of delayed hypersensitivity skin test response despite previous exposure. The coincidence of Marfan''s syndrome and either XXX or immunologic dysfunction was not reported previously. More than 1 abnormality evidently may occur in a single patient.